CBMi Press Releases

CBMi Contributions: New Gene Study of ADHD Points to Defects in Brain Signaling Pathways

Philadelphia, Dec. 4, 2011 –Pediatric researchers analyzing genetic influences in attention-deficit/hyperactivity disorder (ADHD) have found alterations in specific genes involved in important brain signaling pathways. The study raises the possibility that drugs acting on those pathways might offer a new treatment option for patients with ADHD who have those gene variants—potentially, half a million U.S. children.

The study appears online in Nature Genetics.

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CBMi, CHOP, Among Recipients of an NHGRI Four-Year Clinical Sequencing Exploratory Research Project Award

Philadelphia, Dec. 6, 2011 - The Children’s Hospital of Philadelphia is one of five U.S. centers, and the only one focusing on pediatrics, to receive a new four-year Clinical Sequencing Exploratory Research Project award. Children’s Hospital will receive $2.2 million per year for four years. The National Human Genome Research Institute (NHGRI) announced the grant today as part of an intensified focus on the medical applications of its flagship Genome Sequencing Program.

As part of the grant, CBMi's project "Sequencing, Analysis and Interpretation of Sequencing Data" aims to build a framework for systematically assessing the gene sequence data we collect, to integrate the data with medical care.

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Gene Variants in Autism Linked to Brain Development -- Children's Hospital of Philadelphia Study Shows Extensive Complexity of Autism Genetics

New research on the genomics of autism confirms that the genetic roots of the disorder are highly complicated, but that common biological themes underlie this complexity. In the current study, researchers have implicated several new candidate genes and genomic variants as contributors to autism, and conclude that many more remain to be discovered.

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