Career Opportunities with the Center for Biomedical Informatics

14-33358 INFORMATION ANALYST II

The Information Analyst II functions as a member of a multi-disciplinary clinical reporting team whose expertise spans the domains of clinical data systems and reporting, clinical practice, and research processes. The Information Analyst II will generally extract and transform data from a variety of clinical and supporting non-clinical data sources to enable research and quality improvement initiatives leading to research across a rapidly evolving academic research enterprise. This position will develop reporting strategies and execute them under the guidance of practicing physicians and researchers in a project-oriented environment.
The Analyst will have expertise in data validation, loading, and structures and should be able to efficiently manipulate data using a variety of formatting and/or analysis languages such as Perl, Python, Java, etc. In some cases, the amount and complexity of the data will demand careful attention to details of the underlying data model and may result in schema changes or mapping. Effective written and oral communication and a proven customer focus are essential for this position’s direct interactions with world-class biomedical researchers.

Requirements

  • BS in computer science, information science, or related field. Candidates with a degree in the life sciences, but who have pursued a career in informatics are also sought.
  • 2-5 years of Business Intelligence/Data Warehousing experience, preferably in a healthcare environment.
  • 4-5 years of Business Intelligence experience, preferably in a healthcare environment.
  • Working knowledge of SQL and one or more of the following: Perl, Python, Java.
  • Working knowledge of relational database application development is required, including stored procedures, SQL, data definition language, basic performance tuning and query optimization, and ETL techniques.
  • Working knowledge of relational database application development highly desired, including stored procedures, SQL, data definition language, basic performance tuning and query optimization, and ETL techniques.
  • Experience in building databases in REDCap is preferred.
  • Must be able to efficiently translate clinical data modeled within a complex schema into interpretable information for biomedical research activities.
  • Situational awareness concerning data interpretation, quality, and integrity is essential.
  • Must exhibit excellent oral and written communication skills.

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14-33156 LEAD ANALYST/PROGRAMMER

We are seeking an experienced Lead software development professional to join our small, highly focused, entrepreneurial R&D application development group within the Center for Biomedical Informatics (CBMi). As a member of our team, your technical expertise can have an immediate impact on patient care through our mission to accelerate pediatric research with novel applications and data solutions. Furthermore, your work here has the potential to impact the future of healthcare through our research into software solutions supporting genome-enabled personalized medicine. Our research mission fosters an environment where creativity and exploration of new technologies are promoted and encouraged. This role will lead the independent development and implementation of highly creative and reliable tools in order to optimize informatics solutions in the research setting. This position demands an individual with superior technical programming skills in one or more computer languages who can quickly apply this knowledge to define a “best path” for a wide variety of projects. The Lead Analyst/Programmer will independently develop solutions for an academic research organization to yield deliverables such as analysis modules that utilize large and complex data types, data extraction/analysis modules that are dependent on complex underlying healthcare data systems, and integrated systems that promote translation between the biomedical research and clinical domains. The Lead Analyst/Programmer will lead in the acquisition of client requirements, design of solution sets, coding, testing and implementation for programming projects that affect the research community. The individual will be able to very quickly and independently translate requirements from disparate functions into deliverables that are immediately high in quality, extensible as defined by a long-term strategic plan, and intuitively accessed and utilized.

Requirements

  • BS or MS degree in computer science, information science, or related field.
  • 6+ years of programming experience with progressively more complex projects.
  • Mastery of one or more programming language highly desired with a demonstrated ability to learn new languages (Python, JavaScript, or Scala experience is highly desirable).
  • Mastery of unit and integration test design and programming frameworks such as PyUnit or JUnit highly desired.
  • Working knowledge of one or more bug tracking applications such as FogBugz or Trac highly desired.
  • Working knowledge of relational database application development highly desired, including stored procedures, SQL, data definition language, basic performance tuning and query optimization, and ETL techniques.
  • Working knowledge of Python, JavaScript and one or more of the following preferred: Java, PHP, C/C++.
  • Working knowledge of one or more of the following web application framework/platforms preferred: Django, Ruby on Rails, JBoss, Apache Tomcat.
  • Previous experience in data modeling and applications of highly multidimensional data types such as that derived from clinical research, genomics, proteomics, or image analysis is preferred.
  • Experience in healthcare and/or biomedical data management issues is preferred.
  • Demonstrates expert knowledge of test-driven development, unit testing, and the importance and implementation of configuration management processes and technologies.
  • Exhibits excellent oral and written communication skills.
  • Demonstrates knowledge of system integration, configuration, and deployment.
  • Demonstrates ability to document code and systems.

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14-32934 BIOINFORMATICS SCIENTIST

The Bioinformatics Scientist will apply his or her knowledge of bioinformatics algorithms and analysis platforms to consult with investigators on their projects, analyze data and align with biological systems, and to serve as a collaborative, and sometimes lead, investigator in academic output. For this particular position, we are seeking a scientist who specializes in analysis and interpretation of RNA-Seq, CHiP-Seq, and a wide variety of expression array analysis. This individual will work in a highly skilled, team-oriented environment applying knowledge of cellular, molecular, and computational biology to create novel methods and testable scientific hypotheses. Successful candidates will be knowledgeable of the major genomics platforms in a variety of areas, but with a distinct emphasis on whole genome sequencing and tools for the transfer, management, processing, analysis, and interpretation of this data. Candidates will also have an excellent understanding of the strengths and limitations of these platforms as they apply to experimental endpoints and will readily be able to set expectations and defend results through direct communication with principal investigators and their staff. This position will be able to apply a broad range of statistical methodologies such as generalized linear models, multivariate methods, and some machine learning. An expert understanding of systems biology as represented by integrated pathway analysis is expected. This individual must be a functional coder in R, Perl, Python, Java, or other scripting/statistical language. Please note that those individuals that do not possess strong knowledge of molecular biology and systems should not apply.

Requirements

  • PhD required in Informatics, Computational Biology, Genetics, or related discipline
  • 5 or more years experience in bioinformatics analysis, interpretation, and alignment with other biological data and knowledge sources
  • 2 or more years experience in analyzing RNA-Seq, CHiP-Seq, and expression arrays
  • Strong programming skills in at least one scripting language such as R, Perl, Python, or Ruby
  • Strong UNIX/LINUX expertise required.
  • High Performance Computing skills required
  • Previous experience in data modeling and applications of next generation sequencing data is strongly preferred
  • High performance computing skills required.
  • Previous experience in data modeling and applications of next generation sequencing data is strongly preferred.
  • Familiarity with bioinformatics resources and software required.
  • Experience with statistics as it relates to highly multidimensional data is required.
  • Excellent oral and written communication skills are required

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14-32810 BIOINFORMATICS DIRECTOR

The Children's Hospital of Philadelphia is seeking a Bioinformatics Director in the Center for Biomedical Informatics (CBMi). The Director's primary function is to determine innovative and sustainable ways for molecular data and knowledge to be generated and integrated into clinical activities. The position heavily aligns with CHOP’s goal of genome-enabled medicine and reflects the Research Institute’s innovation in genomic technologies, clinical diagnostics, and the practical application of progressive research findings to medical practice. CHOP is deeply committed to translational molecular medicine, including a fully integrated electronic health record, a sizable genomics capacity, a strong commitment to sequence-based genome diagnostics, the world’s largest pediatric biobank, and internationally renowned clinical pediatric expertise.

In collaboration with senior CBMi and CHOP research leadership, the candidate will be responsible for leading strategic informatics initiatives involving bioinformatics research; engaging with and recruiting members of CHOP’s healthcare provider communities as stakeholders for the utilization of molecular knowledge in the pediatric clinical environment; developing effective workflows for generating, analyzing, and delivering actionable genomics and functional genomics information to researchers and clinicians; and seeking out mechanisms for collaboration by leading funded research initiatives to achieve these goals. The candidate will also interface with administrative offices to continually address issues of privacy and security, genetic counseling, intellectual property, and other ethical, legal, and social aspects of genomic medicine. The successful candidate will have a robust academic background and publication record in the area of informatics, genomics, and/or translational medicine and will serve as a key informatics-based representative for the institution. Opportunities for transition to a faculty appointment through the University of Pennsylvania Perelman School of Medicine are possible for appropriately qualified candidates.

Requirements

  • MD or PhD, with specialization in one or more areas of biomedical informatics, genomics, bioinformatics, computational biology, or a closely related field.
  • 10 or more years of experience in a lead research or biomedical position.
  • Strong academic achievement and publication record.
  • Demonstrated leadership of institutional initiatives and research projects.
  • Demonstrated knowledge in current challenges in genomic medicine, including technical, regulatory and privacy, and legal areas.

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NOTE:All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

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The Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

The Children’s Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at The Children’s Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).