Career Opportunities with the Center for Biomedical Informatics

14-32934 BIOINFORMATICS SCIENTIST

The Bioinformatics Scientist will apply his or her knowledge of bioinformatics algorithms and analysis platforms to consult with investigators on their projects, analyze data and align with biological systems, and to serve as a collaborative, and sometimes lead, investigator in academic output. For this particular position, we are seeking a scientist who specializes in analysis and interpretation of RNA-Seq, CHiP-Seq, and a wide variety of expression array analysis. This individual will work in a highly skilled, team-oriented environment applying knowledge of cellular, molecular, and computational biology to create novel methods and testable scientific hypotheses. Successful candidates will be knowledgeable of the major genomics platforms in a variety of areas, but with a distinct emphasis on whole genome sequencing and tools for the transfer, management, processing, analysis, and interpretation of this data. Candidates will also have an excellent understanding of the strengths and limitations of these platforms as they apply to experimental endpoints and will readily be able to set expectations and defend results through direct communication with principal investigators and their staff. This position will be able to apply a broad range of statistical methodologies such as generalized linear models, multivariate methods, and some machine learning. An expert understanding of systems biology as represented by integrated pathway analysis is expected. This individual must be a functional coder in R, Perl, Python, Java, or other scripting/statistical language. Please note that those individuals that do not possess strong knowledge of molecular biology and systems should not apply.

Requirements

  • PhD required in Informatics, Computational Biology, Genetics, or related discipline
  • 5 or more years experience in bioinformatics analysis, interpretation, and alignment with other biological data and knowledge sources.
  • 2 or more years experience in analyzing RNA-Seq, CHiP-Seq, and expression arrays
  • Strong programming skills in at least one scripting language such as R, Perl, Python, or Ruby.
  • Strong UNIX/LINUX expertise required.
  • High Performance Computing skills required.
  • Previous experience in data modeling and applications of next generation sequencing data is strongly preferred.
  • High performance computing skills required.
  • Previous experience in data modeling and applications of next generation sequencing data is strongly preferred.
  • Familiarity with bioinformatics resources and software required.
  • Experience with statistics as it relates to highly multidimensional data is required.
  • Excellent oral and written communication skills are required.

Click here to apply for this position.

Return to Top

14-32810 BIOINFORMATICS DIRECTOR

The Children's Hospital of Philadelphia is seeking a Bioinformatics Director in the Center for Biomedical Informatics (CBMi). The Director's primary function is to determine innovative and sustainable ways for molecular data and knowledge to be generated and integrated into clinical activities. The position heavily aligns with CHOP’s goal of genome-enabled medicine and reflects the Research Institute’s innovation in genomic technologies, clinical diagnostics, and the practical application of progressive research findings to medical practice. CHOP is deeply committed to translational molecular medicine, including a fully integrated electronic health record, a sizable genomics capacity, a strong commitment to sequence-based genome diagnostics, the world’s largest pediatric biobank, and internationally renowned clinical pediatric expertise.

In collaboration with senior CBMi and CHOP research leadership, the candidate will be responsible for leading strategic informatics initiatives involving bioinformatics research; engaging with and recruiting members of CHOP’s healthcare provider communities as stakeholders for the utilization of molecular knowledge in the pediatric clinical environment; developing effective workflows for generating, analyzing, and delivering actionable genomics and functional genomics information to researchers and clinicians; and seeking out mechanisms for collaboration by leading funded research initiatives to achieve these goals. The candidate will also interface with administrative offices to continually address issues of privacy and security, genetic counseling, intellectual property, and other ethical, legal, and social aspects of genomic medicine. The successful candidate will have a robust academic background and publication record in the area of informatics, genomics, and/or translational medicine and will serve as a key informatics-based representative for the institution. Opportunities for transition to a faculty appointment through the University of Pennsylvania Perelman School of Medicine are possible for appropriately qualified candidates.

Requirements

  • MD or PhD, with specialization in one or more areas of biomedical informatics, genomics, bioinformatics, computational biology, or a closely related field.
  • 10 or more years of experience in a lead research or biomedical position.
  • Strong academic achievement and publication record.
  • Demonstrated leadership of institutional initiatives and research projects.
  • Demonstrated knowledge in current challenges in genomic medicine, including technical, regulatory and privacy, and legal areas.

Click here to apply for this position.

Return to Top

14-33778 DATA INTEGRATION ANALYST

The Data Integration Analyst, Enterprise Informatics in Translational Informatics is responsible for the development and operations of integrated research tools, laboratory information systems, reporting applications, data management and analytics systems within a translational research setting for biorepository studies. The focus of this position is the onboarding of new biorepositories which use multiple integrated tools for day-to-day operations and the data requests and ETL processes that come with the nature of these studies. This position demands an individual with superior technical and innovative database creation, administration, and programming skills, as well as diplomatic and organizational skills associated with the successful management of resources within a matrix environment.

This position also requires a large degree of experience in the modeling of highly complex data types such as genomics and proteomics. This individual will interact heavily with Hospital data transformation and integration initiatives to demonstrate proof-of-concept data integration and to promote the proper representation of translational data and activities created and utilized by the diverse researcher population.

Requirements

  • BS required/MS strongly preferred in Computer Science, Information Science, Informatics, or related discipline.
  • 5 or more years experience in database development, database administration, and/or programming within a health sciences environment necessary.
  • 3 or more years experience in medical and research data modeling preferred.
  • Previous experience in data modeling and applications of highly multidimensional data types such as that derived from genomics, proteomics, or image analysis is strongly preferred.
  • Previous experience working in a regulated or audited systems environment preferred.
  • Demonstrates expert knowledge of the Systems Development Life Cycle.
  • Superior oral and written communication skills.
  • Working knowledge of project management and business processes is preferred.

Click here to apply for this position.

Return to Top

14-33779 ANALYST/PROGRAMMER

The Analyst/Programmer in Enterprise Translational Informatics at the Center for Biomedical Informatics (CBMi) is responsible for supervised development and implementation of highly creative and reliable tools in order to optimize informatics solutions in the research setting for bio-repository studies and enterprise translational informatics solutions. Most projects will relate directly and indirectly to the Children’s Brain and Tumor Tissue Consortium, but will have wider enterprise implications. This position demands an individual with superior technical programming skills who can quickly apply this knowledge to define a “best path” for a wide variety of projects. The Analyst/Programmer will develop solutions for a fairly complex organization to yield deliverables such as bioinformatic analysis modules that utilize large and complex data types, data extraction/analysis modules that are dependent on complex underlying healthcare data systems, and process-oriented modules that help maintain patient privacy and further the efficiencies in biorepository studies.

The programmer/analyst will work closely with the Applications Research team in Translational Informatics to understand and execute on client requirements, design of solution sets, coding, testing and implementation for programming projects that affect the bio-repository and translational research community. The individual will be able to very quickly and independently translate requirements from disparate functions into deliverables that are immediately high in quality, extensible as defined by a long-term strategic plan, and intuitively accessed and utilized by users.

Requirements

  • BS/BA required/MS preferred in computer science, biomedical engineering, information science, or related field.
  • One or more years of systems analysis and/or programming experience with progressively more complex projects.
  • Working knowledge of one or more of the following preferred:Python, PHP, Scala, Perl (with BioPerl familiarity), C/++.
  • Working knowledge of relational database application development preferred, including stored procedures, SQL, data definition language.
  • Previous experience in data modeling and applications of highly multidimensional data types such as that derived from clinical research, genomics, proteomics, or image analysis is preferred.
  • Experience in healthcare and/or biomedical data management issues is preferred.
  • Working knowledge of project management and business processes is preferred.
  • Must exhibit excellent oral and written communication skills.
  • Demonstrates knowledge of system integration, configuration, and deployment.
  • Experience with continuous integration, containerization, and automated testing tools and processes is preferred.

Click here to apply for this position.

Return to Top

14-34102 ANALYST/PROGRAMMER

The Analyst/Programmer (Data Science) in the Translational Informatics Unit (TiU) of the Department of Biomedical and Health Informatics is responsible for the supervised development and implementation of highly creative and reliable tools in order to optimize informatics solutions in both clinical and research settings. This position demands an individual with superior data science and programming skills who can quickly apply this knowledge to define a “best path” for a wide variety of projects. The Analyst/Programmer will identify, assess, and implement computational, algorithmic, and predictive analytics approaches to solve a wide variety of problems in the healthcare domain utilizing heterogeneous and complex data types. The individual will contribute to the experimental design, execution, test and evaluation of translational data science research projects defined through collaborative efforts with the research community. The individual will coordinate with other members of the TiU to integrate algorithms in production software. The Analyst/Programmer will communicate methods, implementation, and results to a varied audience of clinicians, scientists, and peers. The individual will contribute to academic dissemination activities such as manuscript writing and conference presentations.

Requirements

  • BS required/MS preferred in mathematics, statistics, biomedical informatics, computer science, information science, or related field.
  • Working knowledge of machine learning methods and experience with at least one machine learning library (e.g. ScikitLearn, Weka).
  • Previous experience with Natural Language Processing (NLP) methods is preferred.
  • Working knowledge of applied mathematical/statistical modeling such as probabilistic graphical models, time series predictive models, and Markov models.
  • Working knowledge of one or more of the following preferred: Scala, Python, R.
  • Relational database application development experience preferred, including stored procedures, SQL, data definition language.
  • Experience with client web application and/or REST services development is preferred.
  • Familiarity with distributed computing technologies (e.g. Akka, MapReduce, Cuda) and Non-SQL stores (e.g. Neo4j, Hadoop) is preferred.
  • Previous experience in data modeling and applications of highly multidimensional data types such as that derived from clinical research, genomics, proteomics, or image analysis is preferred.
  • Must exhibit excellent oral and written communication skills.

Click here to apply for this position.

Return to Top

14-34063 SYSTEMS ANALYST III

As part of the Enterprise Informatics Group in the Center for Biomedical Informatics (CBMi) at the CHOP Research Institute, the System Analyst for Research Laboratory Information Management Systems (LIMS) is responsible for customizing and implementing Thermo-Fisher Nautilus LIMS in support of projects and end-user needs involving plugin/extension development, laboratory workflows, instrument integration, biospecimen data, sample tracking, and storage. The LIMS System Analyst will work closely with multiple groups, including the CHOP Biorepository Core, Clinical and Translational Research Center, and individual laboratories conducting biobanking studies. The LIMS System Analyst will design and implement complex Nautilus workflows, templates (for specimens, tests, and results), and reports based on project and Research Institute needs. The LIMS System Analyst will lead end-user training and education, trouble-shooting, and support of the Nautilus LIMS system.

Requirements

  • BS/BA in Biological Sciences or related scientific or information technology field. with relevant experience in laboratory informatics, medical technology, or laboratory automation .
  • Four to six years of relevant experience in clinical or research laboratory environments highly desired.
  • Relevant experience with Laboratory Information Management Systems (LIMS) specifically Nautilus, LabVantage, STAR LIMS or Soft highly desired.
  • Knowledge of laboratory workflows, instrument integration/interfacing, SQL, relational database concepts.
  • Knowledge and experience with one or more LIMS or clinical LIS platforms (experience with Nautilus a plus).
  • Demonstrated knowledge and understanding of laboratory functions and processes.
  • Thorough knowledge of enterprise software on Windows Platforms.
  • Knowledge of an academic/research medical center’s unique clients and needs, and how that translates into design, implementation, and support considerations regarding a laboratory system.

Click here to apply for this position.

Return to Top

NOTE:All CHOP employees who work in a patient building or who provide patient care are required to receive an annual influenza vaccine unless they are granted a medical or religious exemption.

  • Child Abuse Clearances
  • FBI Fingerprint Clearance
  • Drug Screening

The Children's Hospital of Philadelphia is an equal opportunity employer. We do not discriminate on the basis of race, color, gender, gender identity, sexual orientation, age, religion, national or ethnic origin, disability or protected veteran status.

The Children’s Hospital of Philadelphia is committed to providing a safe and healthy environment for its patients, family members, visitors and employees. In an effort to achieve this goal, employment at The Children’s Hospital of Philadelphia, other than for positions with regularly scheduled hours in New Jersey, is contingent upon an attestation that the job applicant does not use tobacco products or nicotine in any form and a negative nicotine screen (the latter occurs after a job offer).