Application Development News
The AudGenDB Project
The overall objective of this project is to develop an integrated biomedical-computing infrastructure incorporating audiologic, otologic and genetic patient data that will meet the needs of investigators pursuing patient-oriented pediatric hearing research. As the largest pediatric health-care network in the United States, the Children’s Hospital of Philadelphia (CHOP) is uniquely positioned to develop a computational infrastructure for patient data acquired through screening and comprehensive evaluation of pediatric patients with congenital, early-onset, progressive and acquired forms of hearing loss. In the first phase of this project, the overall approach required for building a biomedical-computing infrastructure was determined. Subsequently, a proof-of-concept query of the database containing a limited critical set of data from existing audiologic and genetic databases at CHOP was demonstrated. In the second phase of this project, we are expanding the database to incorporate biomedical characteristics data and genetic material from a large patient cohort, and developing a web-based interface for scientific inquiry of the database in a manner that ensures anonymity of patient information.
Developed by the Center for Biomedical Informatics, the Audiological and Genetic Database (AudGenDB) is a medical and research database resource that supports qualified researchers studying pediatric hearing health. The database draws information from several sources, including electronic health records, audiological instruments, radiological imagery, clinical genetics results, and genomics research records, and makes them accessible to researchers using a powerful, intuitive, web-based query interface.
Currently, the web application for querying the database is in public beta testing, and a phased implementation of the various clinical areas of interest are scheduled; audiology and demographics have been released initially.
The AudGenDB project is led by a team of researchers from the Children’s Hospital of Philadelphia Research Institute, and is funded by the National Institutes on Deafness and Other Communication Disorders of the NIH.
Learn more at http://audgendb.chop.edu/
